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Oncology Center of Excellence Guidance Documents

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OCE Guidance Agenda

The Oncology Center of Excellence (OCE) is sharing potential topics for new and updated guidance documents. While we plan to develop guidance for these topics, this list is not binding, and we may adjust our priorities based on various factors, including new administration initiatives, emerging public health needs, or other circumstances. We may also develop guidance on topics not listed here. 

To comment on these guidance topics, please visit Regulations.gov and reference Docket FDA-2024-N-5352.


Guidance Documents Regarding Oncology and Hematologic Malignancies

TitleTypeDate Posted
Prevention and Treatment of Chemotherapy-Induced Peripheral Neuropathy: Developing Drug and Biological Products in OncologyDraftJanuary 2025
Accelerated Approval and Considerations for Determining Whether a Confirmatory Trial is UnderwayDraftJanuary 2025
Considerations for Including Tissue Biopsies in Clinical TrialsDraftJanuary 2025
Combined Food and Drug Administration and Sponsor Oncologic Drugs Advisory Committee Briefing DocumentDraftDecember 2024
Use of Circulating Tumor Deoxyribonucleic Acid for Early-Stage Solid Tumor Drug DevelopmentFinalNovember 2024
Assessment of Ovarian Toxicity in Premenopausal Adults During Drug Development for Oncologic ProductsDraftNovember 2024
Core Patient-Reported Outcomes in Cancer Clinical TrialsFinalOctober 2024
Considerations for Generating Clinical Evidence from Oncology Multiregional Clinical Development ProgramsDraftSeptember 2024
Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic DiseasesFinalAugust 2024
Bacillus Calmette-Guérin-Unresponsive Nonmuscle Invasive Bladder Cancer: Developing Drugs and Biologics for TreatmentDraftAugust 2024
Diversity Action Plans to Improve Enrollment of Participants from Underrepresented Populations in Clinical StudiesDraftJune 2024
Cancer Clinical Trial Eligibility Criteria: Washout Periods and Concomitant MedicationsDraftApril 2024
Cancer Clinical Trial Eligibility Criteria: Performance StatusDraftApril 2024
Cancer Clinical Trial Eligibility Criteria: Laboratory ValuesDraftApril 2024
Real-Time Oncology Review (RTOR)FinalNovember 2023
Graft-versus-Host Diseases: Developing Drugs, Biological Products, and Certain Devices for Prevention or TreatmentDraftSeptember 2023
Postmarketing Approaches to Obtain Data on Populations Underrepresented in Clinical Trials for Drugs and Biological ProductsDraftAugust 2023
QTc Information in Human Prescription Drug and Biological Product LabelingDraftAugust 2023
Oncology Drug Products Used with Certain In Vitro Diagnostic Tests: Pilot ProgramFinalJune 2023
Clinical Trial Considerations to Support Accelerated Approval of Oncology TherapeuticsDraftMarch 2023
Pharmacokinetic-Based Criteria for Supporting Alternative Dosing Regimens of Programmed Cell Death Receptor-1 (PD-1) or Programmed Cell Death-Ligand 1 (PD-L1) Blocking Antibodies for Treatment of Patients with CancerFinalDecember 2022
Cross Labeling Oncology Drugs in Combination RegimensFinalNovember 2022
Acute Myeloid Leukemia: Developing Drugs and Biological Products for TreatmentFinalOctober 2022
Tissue Agnostic Drug Development in OncologyDraftOctober 2022
Characterizing, Collecting, and Reporting Immune-Mediated Adverse Reactions in Cancer Immunotherapeutic Clinical TrialsDraftOctober 2022
Cancer Clinical Trial Eligibility Criteria: Available Therapy in Non-Curative SettingsFinalJuly 2022
Renal Cell Carcinoma: Developing Drugs and Biologics for Adjuvant TreatmentFinalJune 2022
Bladder Cancer: Developing Drugs and Biologics for Adjuvant TreatmentFinalJune 2022
Advanced Prostate Cancer: Developing Gonadotropin-Releasing Hormone AnaloguesFinalMay 2022
Inclusion of Older Adults in Cancer Clinical TrialsFinalMarch 2022
Expansion Cohorts: Use in First-In-Human Clinical Trials to Expedite Development of Oncology Drugs and BiologicsFinalMarch 2022
Master Protocols: Efficient Clinical Trial Design Strategies to Expedite Development of OncologyFinalMarch 2022
Nonmetastatic, Castration-Resistant Prostate Cancer: Considerations for Metastasis-Free Survival Endpoint in Clinical TrialsFinalAugust 2021
Evaluating Cancer Drugs in Patients with Central Nervous System MetastasesFinalJuly 2021
Premenopausal Women with Breast Cancer: Developing Drugs for TreatmentFinalJune 2021
Chemotherapy-Induced Nausea and Vomiting: Developing Drugs for PreventionDraftMay 2021
COVID-19: Master Protocols Evaluating Drugs and Biological Products for Treatment or PreventionFinalMay 2021
FDARA Implementation Guidance for Pediatric Studies of Molecularly Targeted Oncology Drugs: Amendments to Sec. 505B of the FD&C ActFinalMay 2021
Geriatric Information in Human Prescription Drug and Biological Product LabelingDraftSeptember 2020
Male Breast Cancer: Developing Drugs for TreatmentFinalAugust 2020
Pediatric Study Plans: Content of and Process for Submitting Initial Pediatric Study Plans and Amended Initial Pediatric Study PlansFinalJuly 2020
Pathological Complete Response in Neoadjuvant Treatment of High-Risk Early-Stage Breast Cancer: Use as an Endpoint to Support Accelerated ApprovalFinalJuly 2020
Setting Endotoxin Limits During Development of Investigational Oncology Drugs and Biological ProductsDraftJuly 2020
Cancer Clinical Trial Eligibility Criteria: Patients with HIV, Hepatitis B Virus, or Hepatitis C Virus InfectionsFinalJuly 2020
Cancer Clinical Trial Eligibility Criteria: Patients with Organ Dysfunction or Prior or Concurrent MalignanciesFinalJuly 2020
Cancer Clinical Trial Eligibility Criteria: Brain MetastasesFinalJuly 2020
Cancer Clinical Trial Eligibility Criteria: Minimum Age Considerations for Inclusion of Pediatric PatientsFinalJuly 2020
Developing and Labeling In vitro Companion Diagnostic Devices for a Specific Group or Class of Oncology Therapeutic ProductsFinalApril 2020
Hematologic Malignancies: Regulatory Considerations for Use of Minimal Residual Disease in Development of Drug and Biological Products for TreatmentFinalJanuary 2020
Investigational In Vitro Diagnostics in Oncology Trials: Streamlined Submission Process for Study Risk DeterminationFinalOctober 2019
Placebos and Blinding in Randomized Controlled Cancer Clinical Trials for Drug and Biological ProductsFinalAugust 2019
Oncology Therapeutic Radiopharmaceuticals: Nonclinical Studies and Labeling RecommendationsFinalAugust 2019
Oncology Pharmaceuticals: Reproductive Toxicity Testing and Labeling RecommendationsFinalMay 2019
Considerations for the Inclusion of Adolescent Patients in Adult Oncology Clinical TrialsFinalMarch 2019
Clinical Trial Endpoints for the Approval of Cancer Drugs and BiologicsFinalDecember 2018
S9 Nonclinical Evaluation for Anticancer Pharmaceuticals—Questions and AnswersFinalJune 2018
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