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  1. Science & Research (NCTR)

Mani Chidambaram M.Sc., Ph.D.
Leadership Role

Staff Fellow — Office of Scientific Coordination

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Mani Chidambaram, M.Sc., Ph.D.
(870) 543-7121
NCTRResearch@fda.hhs.gov  

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About  |  Publications 

Background

Mani Chidambaram completed his graduate work at the University of Baroda in India, where he completed course work in chemistry and thesis work in the field of amino acid metal chelates. He continued this field of study at the University College in Dublin, Ireland, where he worked on a joint project within the Chemistry and Agriculture Departments involving inorganic metal complexes; various physical chemistry techniques (both structural and kinetic) were used to correlate the observed biological activities with their chemical properties. He then went to Florida State University, where he worked on a research project on the biochemistry of Ceruloplasmin, a blue copper protein from plasma of vertebrates. Ceruloplasmin was isolated from the blood of various animals and then characterized their enzymatic and biological activities. At Texas A&M University, Dr. Chidambaram then conducted research on in vitro and in vivo models of human iron nutrition.  Physicochemical methods were developed for the characterization of iron in the contents of the digestive tract and the interrelationships between digestive chemistry and bioavailability of iron-containing foods. Dr Chidambaram then came to Little Rock, where he worked in the College of Pharmacy at the University of Arkansas Medical Sciences (UAMS) on the synthesis of substituted salicylic acids and their copper complexes using radioactive labels. He then worked at an Arkansas Department of Health laboratory, where he analyzed and quantified fat, organochlorine pesticides, and toxins in milk and other dairy products.

Dr. Chidambaram joined NCTR in the Biochemical Toxicology Division in the Analytical Chemistry Support group, where he has participated in the analysis of various compounds of interest to NCTR and the FDA. Over the years, this has included studies to certify and verify the dose levels of numerous compounds, such as HIV drugs, bisphenol-A, aloin A and aloin B, triclosan, doxorubicin, dexrazoxane, methylphenidate, oseltamivir phosphate, Arsenic (III), and Arsenic (V). Most recently, Dr. Chidambaram joined the Office of Scientific Coordination in the Analytical Chemistry Group, where he has developed qualitative and quantitative analytical methods for the analysis of twelve cannabinoids in cannabis leaf, smoke, and vapor samples. He has also developed quantitative methods for the analysis of synthetic CBD in sesame oil formulations and studied stability of the compound in this commercially-relevant formulation. 

Research Interests

Dr. Chidambaram is interested in:

  • Quantitative analytical chemistry techniques including solid phase extraction, high performance liquid chromatography (HPLC/UPLC), gas chromatography (GC), HPLC-mass spectrometry, GC-mass spectrometry. Trace level analysis of toxic or suspect compounds in various matrices, including food, drug formulations and biological samples, such as plasma, urine and tissues.
  • Synthesis and characterization of organic molecules of medicinal interests.
  • Synthesis and characterization of metal complexes of biological interest and their characterization by physical chemistry techniques such as spectroscopy, magnetic susceptibility measurements, electron spin resonance spectroscopy, circular dichroism, and atomic absorption spectrophotometry.
  • Metal-protein interactions, including exchange reactions involving stopped-flow techniques, radioactivity, gel-filtration, electrophoresis, oxygen concentration measurements, isolation of proteins from serum and plant materials. Special interest in trace elements, especially iron and copper.

Selected Publications

Toxicity Evaluation of Bisphenol A Administered by Gavage to Sprague Dawley Rats from Gestation Day 6 Through Postnatal Day 90.
Delclos K.B., Camacho L., Lewis S.M., Vanlandingham M.M., Latendresse J.R., Olson G.R., Davis K.J., Patton R.E., Gamboa da Costa G., Woodling K.A., Bryant M.S., Chidambaram M., Trbojevich R., Juliar B.E., Felton R.P., and Thorn B.T.
Toxicol Sci. 2014, 139(1):174-97. doi: 10.1093/toxsci/kfu022. Epub 2014 Feb 4. 

Pharmacokinetic Distribution of 67Cu(II)2[3,5-Diisopropyl(Carboxy- 14C)Salicylate]4 Among Murine Tissues. 
Blincoe C., Chidambaram M., Salari H., Bond K., Evans D.T., Gray-Kaufman R.A., Griffey H.B., Tranby S.G., Garner-Johnson B., Lee T., and Sorenson J.R.J. 
Current Medicinal Chemistry. 2004, 11(22). :3007.

In Vitro Studies on Iron Bioavailability: Probing the Concentration and Oxidation-reduction of Pinto Bean Iron with Ferrous Chromogens.
Chidambaram M.V., Reddy M.B., Thompson J.L., and Bates G.W. 
Biol. Trac. Elem. Res. 1989, (19) :25 

Contact Information
Mani Chidambaram
(870)543-7121
Expertise
Expertise
Approach
Domain
Technology & Discipline
Toxicology
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