U.S. flag An official website of the United States government

On Oct. 1, 2024, the FDA began implementing a reorganization impacting many parts of the agency. We are in the process of updating FDA.gov content to reflect these changes.

U.S. Food and Drug Administration
  1. Home
  2. Drugs
  3. Development & Approval Process | Drugs
  4. Development Resources
  5. Drug Interactions & Labeling
  6. Ventricular Arrhythmia (Torsades de Pointes) Occurring in Association with Terfenadine Use
  1. Drug Interactions & Labeling

Ventricular Arrhythmia (Torsades de Pointes) Occurring in Association with Terfenadine Use

Monahan BP et al. JAMA 1990;264:2788–2790
  • 39 y.o. female with 2-day Hx of intermittent syncope
  • Rx with terfenadine 60 mg bid and cefaclor 250 mg tid ? 10 d
  • Self-medicated with ketoconazole 200 mg bid for vaginal candidiasis
  • Palpitations, syncope, torsades de pointes (QTc 655 msec)

 

Back to Learning Module

Back to Top