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  5. Hybridomas Secreting Novel Monoclonal Antibodies Against the Nucleoprotein Of Influenza Virus
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Hybridomas Secreting Novel Monoclonal Antibodies Against the Nucleoprotein Of Influenza Virus

Download the Abstract (PDF - 0.85MB)

Technology Summary

Influenza A viruses pose a serious threat to public health. The nucleoprotein (NP) of an influenza virus is a highly conserved protein involved in the transcription, replication and packaging of the viral genome, influencing the virulence of the virus within the host.

This invention is a hybridoma that secrets monoclonal antibodies that can broadly-react against the NP of influenza viruses. The antibodies, designated G20, A40 and A60, were specifically raised against the NP of the H3N2 virus A/Minnesota/11/2010.

Potential Commercial Applications Competitive Advantages
  • Research tool
  • Development of a clinical diagnostic for rapid detection of influenza virus infection
  • Broadly react with the NP of all tested subtypes of Influenza A viruses
  • Antibody G20 has strong reactivity with the NP of equine H3N8 virus

Development Stage: Research reagent

Inventors: Hongquan Wan

Product Area:  Bioassay, diagnostics, vaccine

FDA Reference No:E-2018-007  

Licensing Contact:
Bill Ronnenberg, MS, JD/MIP
FDA Technology Transfer Program
Email: FDAInventionlicensing@fda.hhs.gov
Phone: 240-402-4561

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