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AURA3: Chills

Project Patient Voice is intended to be used with a healthcare professional when discussing the potential symptoms related to a cancer and cancer treatment. Do not rely on Project Patient Voice alone to make decisions about medical care. Do not use Project Patient Voice to substitute for advice from your health care professional. Conclusions about patient experiences with symptoms may be limited because not all symptoms may have been captured by the patient-reported questionnaire.

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In AURA3 Study, Patients Were Asked: "In the last 7 days, how OFTEN did you have SHIVERING OR SHAKING CHILLS?"

Patients scored the frequency of their Chills on a 5-point scale (Never, Rarely, Occasionally, Frequently, Almost Constantly)

Patient-Reported Chills During the First 24 Weeks on Treatment for Patients Who Completed a Questionnaire:

Figure 1 shows the percentage of patients reporting how often they had Chills at each time point. For example, at week 2, 17% of patients taking Tagrisso reported Chills (ranging from Rarely to Almost Constantly). The range of patients who reported having any amount of Chills during the first 24 weeks of treatment with Tagrisso was between 11% - 21%. Click here for more information on how to read the graphs below.

Figure 1. Patient-Reported Chills During the First 24 Weeks on Treatment

Two stacked bar charts, one for Tagrisso and the other for chemotherapy, showing proportion of patients reporting the frequency of chills at each time point through the first 24 weeks of treatment. For example, at week 2, 17% of patients taking Tagrisso reported chills (ranging from Rarely to Almost constantly).

All responses from patients' experiences just before and up to week 24 on-treatment were included in the analysis. Some patients did not report their symptoms every week, therefore the number of patients may vary between weeks. Furthermore, not all patients remained on the treatment for 24 weeks (e.g., some stop treatment for worsening disease) which is a reason for the change in the number of patients over the course of treatment.

Worst Response Option for Chills That Patients Reported During the First 24 Weeks on Treatment

Figure 2. Worst Patient-Reported Chills During the First 24 Weeks on Treatment

Two pie charts, one for Tagrisso and the other for chemotherapy, summarizing the percentage of patients by worst reported chills during the first 24 weeks of the clinical trial. In the Tagrisso arm, Never (55%), Rarely (17%), Occasionally (20%), Frequently (7%) and Almost constantly (1%). In the chemotherapy arm, Never (31%), Rarely (24%), Occasionally (36%), Frequently (5%) and Almost constantly (4%).

Patients with at least one on-treatment Chills score were included in the analysis. Tagrisso (N=99), Chemotherapy (N=55).

Some Patients Did Not Report Chills Before Treatment:

For patients that did not report Chills before treatment, Figure 3 shows the percentage of patients reporting how often they had Chills between weeks 1 and 24.

Figure 3. Patient-Reported Chills During the First 24 Weeks on Treatment: Patients Without Chills Before Treatment

Two stacked bar charts, one for Tagrisso and the other for chemotherapy, which includes only those patients who had no chills before treatment. The bar charts show the proportion of patients reporting frequency of chills at each time point through 24 weeks. For example, at week 2, 9% of patients taking Tagrisso reported chills (ranging from Rarely to Occasionally).

All responses from patients who did not report Chills before treatment were included in the analysis. Some patients did not report their symptoms every week, therefore the number of patients may vary between weeks. Furthermore, not all patients remained on the treatment for 24 weeks (e.g., some stop treatment for worsening disease) which is a reason for the change in the number of patients over the course of treatment.

Worst Response Option for Chills That Patients Reported During the First 24 Weeks on Treatment, for Patients Who Did Not Have Chills Before Treatment:

Figure 4. Worst Patient-Reported Chills During the First 24 Weeks on Treatment: Patients Without Chills before treatment

Two pie charts, one for Tagrisso and the other for chemotherapy, which includes only those patients who had no chills before treatment. The pie charts summarize the percentage of patients by worst reported chills. In the Tagrisso arm, Never (66%), Rarely (13%), Occasionally (14%), Frequently (7%) and Almost constantly (0%). In the chemotherapy arm, Never (42%), Rarely (24%), Occasionally (24%), Frequently (3%) and Almost constantly (7%).

Patients who had no Chills before treatment and at least one on-treatment Chills score were included in the analysis. Tagrisso (N=59), Chemotherapy (N=33).

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