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GUIDANCE DOCUMENT

M10 Bioanalytical Method Validation and Study Sample Analysis November 2022

Download the Final Guidance Document Read the Federal Register Notice
Final
Docket Number:
FDA-2019-D-1469
Issued by:
Guidance Issuing Office
Center for Drug Evaluation and Research
Center for Biologics Evaluation and Research

The guidance describes recommendations for method validation for bioanalytical assays for nonclinical and clinical studies that generate data to support regulatory submissions, including the procedures and processes that should be characterized for chromatographic and ligand-binding assays that are used to measure the parent and active metabolites of drugs administered in nonclinical and clinical subjects. The guidance is intended to provide industry with harmonized regulatory expectations for bioanalytical method validation of assays used to support regulatory submissions. The guidance replaces the draft guidance “M10 Bioanalytical Method Validation” issued on June 27, 2019.

M10 Bioanalytical Method Validation and Study Sample Analysis - Questions and Answers

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All written comments should be identified with this document's docket number: FDA-2019-D-1469.

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