Bioinformatics Tools
Tools created at NCTR to develop methods for the analysis and integration of complex omics datasets
The National Center for Toxicological Research conducts research in both bioinformatics and chemoinformatics. The Center also develops and coordinates bioinformatics capabilities within NCTR, across FDA Centers, and in the larger toxicology community. These Bioinformatics Tools were created at NCTR with the goal of developing methods for the analysis and integration of complex omics (genomics, transcriptomics, proteomics, and metabolomics) datasets. The list of Bioinformatics Tools are listed below:
For best results, use the Firefox browser with Java 8 under Windows 7 or 10 when using the bioinformatics tools.
For best results, use the Firefox browser with Java 8 under Windows 7 or 10 when using the bioinformatics tools.
- ArrayTrack™ HCA-PCA Standalone Package
Hierarchical Cluster Analysis (HCA) and Principal Component Analysis (PCA) – powerful data-exploring tools extracted from ArrayTrack™. - Database of Pharmacogenomic Information in Ethnic Minority Populations (dbPGxEMP)
Integrative database linking drugs, pharmacogenomic biomarkers, and genetic variations in minority populations. - The de novo Assembly Quality Evaluation Tool (dnAQET)
Framework designed to evaluate the contigs of a de novo assembly against a trusted reference genome. - Decision Forest
Novel pattern-recognition method for analysis of data from microarray experiments, proteomics research, and predictive toxicology. - Estrogenic Activity Database (EADB)
Comprehensive set of estrogenic activity data from a variety of data sources and a component of the enhanced Endocrine Disruptors Knowledge Base (EDKB). - Endocrine Disruptor Knowledge Base (EDKB)
Scientific resources for estrogen and androgen activity of potential endocrine disruptor chemicals. - FDALabel – An FDA Drug Labeling Search Tool
Tool to conduct full-text search of drug labeling. - Liver Toxicity Knowledge Base (LTKB)
Collection of diverse drug-induced liver injury data associated with individual drugs and development of predictive models to assess risk of drug-induced liver injury.- Drug-Induced Liver Injury Rank (DILIrank) Dataset
A large reference list of drugs divided into four classes by their risk for developing DILI in humans. - Drug-Induced Liver Injury Severity and Toxicity (DILIst) Dataset
A large reference list of drugs divided into two classes by their risk for developing DILI in humans.
- Drug-Induced Liver Injury Rank (DILIrank) Dataset
- Drug-Induced Cardiotoxicity Rank (DICTrank) Dataset
The largest reference list of human drugs ranked by risk of drug-induced cardiotoxicity using FDA labeling. - Drug-Induced Renal Injury List (DIRIL) Dataset
A large database of single-molecule, oral administered drugs for human use annotated for DIRI and nephrotoxicity. - MicroArray/Sequencing Quality Control (MAQC/SEQC)
Project to develop microarray quality control metrics and thresholds. - Mold2
Software that generates molecular descriptors from two-dimensional structures.
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Contact NCTR Bioinformatics Support
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Contact NCTR Bioinformatics Support
Contact Point
National Center for Toxicological Research
Food and Drug Administration
3900 NCTR Rd
Jefferson, AR 72079
Food and Drug Administration
3900 NCTR Rd
Jefferson, AR 72079
(870) 543-7538
Hours Available
National Center for Toxicological Research